How to make saline nasal spray

Keri Peterson, MD, is board-certified in internal medicine and operates a private practice, Age Well, in New York City.

A saline nasal spray is a simple saltwater solution that can be used by both children and adults.   It may help give you relief from nasal dryness (helping prevent nosebleeds), congestion associated with the common cold or allergies, or even snoring. It can also be a useful adjunctive (supplemental) treatment if you have obstructive sleep apnea. They typically come in a squirt bottle or pump bottle for direct use inside the nose, and are available over the counter (OTC). Saline nasal spray has little risk of side effects and can be used as often as needed.

How to make saline nasal spray

What Is Nasal Saline Spray?

Most saline nasal sprays contain sterilized water, salt (sodium chloride), and sometimes preservatives to give them a longer shelf life. The usual delivery system is a squirt bottle or pump bottle. Similarly, there are saline nasal drops for infants, which use a dropper.

Saline nasal sprays can be purchased without a prescription in most pharmacies or even at a grocery store in the medicine aisle. There are numerous store and brand names, including variations on several themes: Ocean Mist, Ocean Spray, Ocean, Simply Saline Nasal Mist, etc. These products are not expensive, often available for just a few dollars but always less than $10.

You can also make your own saline nasal spray and use it with a small squirt bottle.

There are a number of conditions that might be improved with the use of the nasal saline spray. These include:

If you have a condition for which steroid nasal sprays are prescribed, your healthcare provider may recommend using saline nasal spray before each application.

Some people with obstructive sleep apnea may also use the nasal saline spray to reduce nasal congestion at night when using CPAP. As it may rinse out particles called allergens, this may reduce swelling of the mucosa lining the nose. This can improve airflow through the nose and prevent mouth breathing (which may also contribute to snoring).

A benefit of saline nasal spray is that there is no risk of rebound congestion (with stuffiness becoming chronic as the medication wears off). This problem might occur with prolonged use of decongestant nasal sprays such as Afrin (oxymetazoline).


A saline spray can be applied through the nostrils as often as your symptoms require. It can be used daily without potential harm. The effects may be relatively short-lived, requiring multiple uses per day. If it is overused, you may simply notice a runny nose as the excess water drains out.


Saline nasal spray safe for children and adults to use. For infants, saline nasal drops are preferred.

It does not interact with other medications, but if using saline nasal spray along with medicated nasal sprays (such as a steroid nasal spray), it should be used first. If you use it after applying a medicated nasal spray, you may rinse out the medication and therefore reduce its effectiveness.

How to Take Nasal Saline Spray

Review the product instructions to determine the best way to use your spray.

For general guidelines, follow these steps:

  1. You can be in an upright position, and you do not need to tilt your head back.
  2. Clear your nostrils by gently blowing your nose.
  3. Close the nostril you are not going to apply the spray to by pressing your finger against it.
  4. Place the spray bottle under the nostril to which you are applying it to an aim away from the septum (the middle of your nose) so you don’t damage it.
  5. Close your mouth and inhale slightly through the nostril while gently squeezing or pumping the spray applicator. The usual instructions are to apply two squeezes.

Make Your Own

You can make your own saline nasal spray from table salt and tap water. The simple recipe is to mix 1 teaspoon of salt into 1 quart of tap water. For safety, boil the salt water for 20 minutes, then cool it until it is lukewarm.   Use with a clean squeeze bottle.

Side Effects

If you notice any stinging, it may be due to preservatives in the saline nasal spray you are using. In that case, look for preservative-free products or make your own saline solution.


Depending on your symptoms, there may be other effective treatment options. For example, some benefit from the use of a Neti pot with saline solution to relieve allergies or to clear nasal congestion.

If you have ongoing problems with nasal or sinus congestion, see your healthcare provider so your problem may be properly diagnosed and addressed.

The use of other allergy treatments or surgery—including turbinate reduction—may even be a possibility, depending on the nature of the problem. Speak with your healthcare provider about what might work best for you, but starting with nasal saline spray is a safe and effective option.

How to make saline nasal sprayGet the amazing results of the neti pot. without the pot! Snoot! Nasal Cleanser is everything you want from a Neti-Pot squeezed into a tiny little nasal sprayer. You can carry it in your purse, briefcase, gym bag, whatever, and wherever. It goes wherever you go. A couple of squirts, clear your nose, and you’re ready to go.

Snoot! Cleanser is drug-free, will not interfere with other medications, and outperforms neti pots and saline rinses. People choose Snoot 10-to-1 over them. People use Snoot! for:

The High-Tech Neti Pot Alternative

Snoot! Cleanser has all three types of ingredients that you’ll find in a traditional neti pot solution, but does it high-tech: Snoot! has the best blend of acidifiers, carbonates and salts of any sinus rinse. As a result, it uses a lot less water.

How to make saline nasal spray

Snoot! Cleanser’s total salinity is slightly less than 0.9 percent so as to not damage your cilia or add sodium needlessly to your body. (Your body has a natural salt level (salinity) of about 0.9 percent.)

Snoot! contains acidified sodium chlorite for its superior cleansing capabilities, and sodium carbonate – which when acidified also helps you to loosen mucus. Snoot! also contains glycerin and a food-grade surfactant (polysorbate)to make water “wetter” and help you get Snoot! onto your nasal surfaces and into your sinus passages.

When you use Snoot! you’ll get a good rinse with about one milliliter of spray. that’s about a 30th of an ounce, a fifth of a teaspoon. ( The typical neti pot rinse is about 8 ounces.)

That means that you’ll get a whole month of neti pots or saline rinses in every Snoot! kit you buy. It comes in a travel-friendly 4-oz size box and with an even smaller sprayer. Each box fills the sprayer 5-6 times and will last you over a month of continuous use!

How to make saline nasal spray

We’ve provided the chart on the right to highlight some of the big differences between the typical neti pot device and Snoot! Nasal Cleanser. Snoot! is much easier to use and much more convenient.

Mix it once, use it for a week.

Mixing neti pot solution is a bit of a pain — you need a stove or microwave to make clean (boiled) water (note: you must use sterile water in a neti pot in order to use it safely). Even if you have purified water on hand, you still may need to warm it in order to mix better with the neti mix, and for comfort when it is in your nasal passages. That takes a little while to do as well, usually several minutes. And you need to do it EACH and EVERY TIME you use the neti.

Snoot! Nasal Cleanser’s sterile solution requires mixing only once per 5-7 days, you can mix it pretty much anywhere, and it takes just a minute or so to measure the two solutions and mix them into the handy Snoot! sprayer. With Snoot! you don’t need a kitchen, microwave, or water.

A no-mess, 10-second neti pot.

Neti pots are messy, and Snoot is not! With Snoot! you don’t need a bathroom or a sink. It is as fast as easy as just a couple of squirts up each nostril and then a quick blow with a tissue. There is not “pot” left to clean and dry after each use. Just replace the sprayer’s protective cap and get back to whatever you were doing. within seconds.

Snoot! goes with you ANYWHERE.

Snoot! was designed for convenience. Its handy 20ml nasal spray bottle lets you carry 5-7 days of Snoot! with you wherever you go. You can use it in a meeting, on the airplane or in the airport, at the gym, and pretty much everywhere that you WOULD NOT want to be seen using a neti pot.

What Snoot! users say.

How to make saline nasal spray

The chart on the right shows the results of a survey that has been running since 2012. People who use Snoot! prefer it more than 10-to-1 over neti pots and saline. Snoot! Nasal Cleanser has given people sinus relief and freed them from a cycle of seemingly endless misery. They say that they’ll never use their neti pot again.

Pretty much everyone loves Snoot! Cleanser. The real question is whether it will help you. and there is only one way to find out — give it a try. We’ll make that even easier for you by making it risk-free. Try Snoot for 14 days and if you don’t like it, we’ll refund your money with our No-Hassle, 100% money-back guarantee.

It’s that simple. And you can keep the Snoot! for free. How can we do that? People who love Snoot! Cleanser tell other people.

Each package of Snoot! contains enough solution to fill the handy sprayer six times — over a month of continuous use! That’s less than you would pay for most other nose and sinus products that don’t last as long, don’t work very well and don’t come with a guarantee.

So if you’re going to try Snoot! Cleanser, here’s one more thing. Research suggest that up to 30% of the population has some form of sinusitis that they have seen a doctor for, and even more have what is called “sub-clinical” sinusitis, where they are not really happy with their sinuses, but not so unhappy that they have gone to a doctor.

That means that at least half the people you know have some form of sinus challenge, whether it is from flu or colds, fungal sinusitis, rhinitis, or any of a dozen or more sinus and nasal maladies that don’t really have cures. This is a great deal if you want to share Snoot! with someone else who is suffering.Call us anytime at 866-611-7724 with questions – we are happy to help!

Snoot! Nasal Cleanser is not intended to diagnose, treat, cure or prevent any disease.

This product is used to treat dryness inside the nose (nasal passages). It helps add moisture inside the nose to dissolve and soften thick or crusty mucus. In babies and young children with stuffy noses who cannot blow their noses, using this product helps to make the mucus easier to remove with a nasal bulb syringe. This helps relieve stuffiness and makes breathing easier.This product contains a purified gentle salt solution (also called saline or sodium chloride solution). It does not contain any medication.

How to use Ayr Saline Spray, Non-Aerosol

Spray this product into each nostril as needed or as directed by your doctor. This product may also be given into the nose as drops or a stream. Follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

Try not to touch the container tip to the inside of your nose. If this happens, rinse the tip with hot water and dry with a clean tissue before recapping the container.

If your condition persists or worsens, or if you think you may have a serious medical problem, seek immediate medical attention.

Side Effects

Side effects usually do not occur with use of this product. However, if the inside of your nose is very dry and irritated, stinging may occur. If this effect persists or worsens, tell your doctor or pharmacist promptly.

If your doctor has directed you to use this medication, remember that he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada – Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before using this product, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details

This product is safe to use during pregnancy.

This product is safe to use if you are breast-feeding.


If you are using this product under your doctor’s direction, your doctor or pharmacist may already be aware of possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

How to make saline nasal spray

Another sneeze, another sniffle. You can’t wait to get ahold of your non-prescription nasal decongestant spray so you can find relief for your stuffy nose — ASAP.

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“While nasal congestion can be easily treated with an over-the-counter nasal spray, using the spray is not as simple as it might seem,” says pharmacist Jessica Kravchuck, PharmD, RPh. “Correct positioning and technique is key to getting the best results.”

Proper positioning matters

Your favorite nasal spray works by shrinking the blood vessels and tissues in the sinuses, which a cold, allergies or the flu can cause to become swollen and inflamed. To use them properly, it’s important to make sure to point the nasal spray toward the back of the nose so that you can inhale the medicine.

“You never want the spray to be directed right at the nasal septum, which is the middle portion of your nose,” says Dr. Kravchuck. “When you push a spray directly onto the septum, the spray can damage the tissue, and you can end up with some irritation or a bloody nose.”

Here are a few other suggestions for using a nasal spray:

  • Before applying, gently blow your nose. This will clear your nasal passages and clear the way for the medicine.
  • Read the product directions. Be sure to shake the bottle or squirt a small amount out if so directed, which is called priming a nasal inhaler.
  • Close one nostril by pressing your finger against it. Position the bottle opening under the other nostril.
  • Gently squeeze or pump the bottle and inhale slightly and gently with your mouth closed.

Most products can be applied while you are in an upright position, so you don’t have to tilt your head back. Afterward, try to avoid blowing your nose or sneezing, and if necessary, sniff hard a few times to ensure the product remains inside and can go to work.

For proper safekeeping, don’t share it with anyone to avoid sharing bacteria.

“Keep the bottle clean and only allow one person to use it,” she says. “Remember to wipe down the nasal spray bottle and put the cap back on after each use. You never want to share your product with someone else.

The possibility of the rebound effect

Have you ever used a nasal spray for days on end and all of a sudden you stopped feeling relief? What you may have experienced is called the rebound effect.

“Nasal sprays aren’t addicting, but they can become habit-forming and in general, you shouldn’t use them for more than three days,” says Dr. Kravchuck. “Using them longer invites building up a tolerance to the medicines, which is called the rebound effect.”

Along with that comes common minor side effects, too. These can include a bitter smell or taste, sneezing, runny nose and nasal irritation, including burning and stinging. If you experience any major side effects, including a change in heart rate, tremors, unusual sweating or persistent nosebleeds, consult your doctor.

While most people can use these sprays, your doctor or pharmacist may have other recommendations if you suffer from diabetes, high blood pressure, hyperthyroidism or if you’re taking other medications.

“You shouldn’t use a nasal spray if your nasal passages become damaged,” she says. “When this happens, you might need more medicine to control your congestion, or your congestion might worsen if you stop using the spray.”

If this happens, your doctor may suggest you stop using the spray for several weeks to reverse this effect.​​

Data show a simple nasal spray can neutralize the SARS-CoV-2 virus and help alleviate symptoms of COVID disease, but the feds block any mention of these benefits.

The FDA and the FTC have sent warning letters to at least five companies marketing a wide range of antiseptic nasal sprays containing xylitol, saline, povidone-iodine, or some combination of these ingredients. The companies cited studies demonstrating their nasal sprays were able to neutralize and kill the coronavirus. We also have learned that the nose is the dominant site where the virus replicates and infects other areas of the body. Rather than widely disseminating this important public health information, the FTC and the FDA are ruthlessly banning this information and taking these companies to court to silence them. The CDC, whose mission is to increase the “health security” of our nation, has flatly refused to advise Americans to use nasal rinses despite the mountain of evidence showing they work. This highlights everything wrong with our healthcare system.

What kinds of claims were these companies making that required the government to clamp down? Xlear, which makes a nasal spray with xylitol, saline, and grapefruit seed extract, was censored by the FTC for simply discussing the results of more than a dozen studies demonstrating the plausibility of using its nasal spray to help with COVID. These studies show that Xlear destroyed 99.9 percent of the SARS-CoV-2 virus, that xylitol blocks the adhesion of bacteria and viruses, including SARS-CoV-2, to human tissue, and that the use of nasal sprays for COVID decreases viral activity in the nasal pathway, prevents transmission, expedites recovery, decreases disease severity, and reduces hospitalization and mortality.

Might this be useful information for the government to share with us during a global pandemic, with viral variants continually popping up and throwing vaccine effectiveness into question? Undoubtedly, but the FTC has attempted to ban the company from sharing this information. In fact, the FTC has sued Xlear for refusing to take down the “unsupported” health claims from its website that it’s nasal sprays can prevent or treat COVID, showing just how far the government will go to throttle natural options to stay healthy and protect drug and vaccine industry profits.

Not only has the federal government prevented these companies from disseminating this scientifically supported information; they have refused requests to alert the public themselves. Primary care physicians and pulmonologists have petitioned the CDC to issue guidance on the use of nasal sprays to blunt the virus’s impact. The CDC didn’t budge.

What is galling about the government’s actions here is that, for many months at the beginning of the pandemic, there were no other options. Given that substances like xylitol, povidone iodine, and saline are remarkably safe, why not share this information? When the available evidence suggests that these products can help, they are safe, and there aren’t other solutions, it is lunacy not to share this information.

The FTC is also censoring health information about povidone iodine, another ingredient in nasal sprays and mouthwashes. A randomized clinical trial found that a povidone iodine mouthwash, gargle, and nasal spray significantly reduced the viral load in patients with mild to moderate COVID-19. Other evidence shows that an iodine mouth-rinse for 30 seconds can prevent the virus from attaching to oral and nasal tissues. For these reasons, iodine has been used as a prophylactic measure across the globe to reduce disease transmission. Oral rinses have also been found to reduce infections after heart surgery. The Frontline COVID-19 Critical Care Alliance recommends a twice daily antiseptic mouthwash that includes povidone iodine, cetylpyridinium chloride, and essential oils. An iodine-containing nasal spray is also a plausible prophylactic based on the above evidence.

This is all part of a widespread censorship campaign against supposedly fraudulent products making COVID-19 health claims. The FTC and FDA assert that these companies violated federal law simply by describing the studies showing how nasal irrigation can help with COVID, and only drugs that are FDA-approved can claim to prevent, treat, or mitigate a disease.

As we’ve explained before, FDA-approval requires randomized controlled trials (RCTs), which are incredibly expensive. Drug companies can afford them because their drugs are patentable, and the research costs can be recouped once the drug gets approved. Natural products are generally not strongly patentable, so the companies cannot afford the astronomical sums required for RCTs.

The point isn’t that nasal sprays are a magic COVID bullet. The point is that, during a pandemic, the government should embrace an “all of the above” approach to a novel public health problem, informing the public about safe therapies that can plausibly be expected to help. It is lunacy to expect us to wait for clinical trials before a medicine is recommended for COVID. The truth seems to be that, if it isn’t a vaccine, the government doesn’t want to hear about anything that can help with COVID.

Action Alert! Write to the FTC, CDC, and FDA, urging them to alert the public about the benefits of nasal irrigation for staying healthy during the pandemic. Please send your message immediately.

Author: Alliance for Natural Health-USA

The Alliance for Natural Health USA (ANH-USA), led by Gretchen DeBeau, is the largest organization in the US and abroad working to protect your right to utilize safe, effective, and inexpensive healing therapies based on high-tech testing, diet, supplements, and lifestyle changes. We believe a system that is single-mindedly focused on “treating” sick people with expensive drugs, rather than maintaining healthy people, is neither practical nor economically sustainable. ANH-USA is part of an international organization dedicated to promoting natural and sustainable health—and, in particular, consumer freedom of choice in healthcare—through good science and good law. We utilize grassroots advocacy, effective lobbying, litigation, strategic coalitions, and public education campaigns to fight for your right to stay healthy, naturally.

HAMILTON, BERMUDA / ACCESSWIRE / November 12, 2021 / Altamira Therapeutics Ltd. (NASDAQ:CYTO), a company dedicated to addressing unmet medical needs through RNA therapeutics, allergy and viral infection protection, and inner ear therapeutics, announced today positive efficacy data from testing its Bentrio™ nasal spray in vitro against the Delta variant of the SARS-CoV-2 virus.

Bentrio™ is a drug-free nasal spray for protection against airborne viruses and allergens, which has previously shown positive outcomes in a test against the Alpha variant of the virus.

For the Delta variant study, Bentrio TM or saline control were applied in the same type of assay either prophylactically 10 minutes prior to or therapeutically 24 hours following viral inoculation of reconstituted nasal epithelium cells from human donors, followed by once daily application for four days. In saline-treated control cultures, SARS-CoV-2 replicated efficiently, resulting in a rapid increase in viral titer (as measured by the Median Tissue Culture Infectious Dose, TCID50). In contrast, at Days 3 and 4 both prophylactic and therapeutic treatment with Bentrio™ resulted in significantly lower virus titers, reaching -83% when the application was started prior to infection, and -69 to -85% when the application was initiated only when the infection was already ongoing (all values significant at p<0.01 and <0.05).

“We are very pleased to see the protective effects of Bentrio against SARS-CoV-2 confirmed also with the highly contagious and fast replicating Delta variant,” commented Thomas Meyer, Altamira Therapeutic’s founder, Chairman and CEO. “These fresh results provide further support for the broad applicability of Bentrio. By forming a protective film on the nasal mucosa and trapping particles, Bentrio has a purely physical mode of action and is thus suitable for use across different types of viruses and virus variants. We look forward to continuing the commercial roll out of the product, making it available to all those seeking protection.”

As previously reported, Altamira plans to further confirm Bentrio TM ‘s efficacy and safety in a COVID-19 clinical trial. While awaiting study approval by the Drugs Controller General of India, Altamira is also preparing for the conduct of another trial, which may be conducted in lieu of or in combination with the planned trial in India.

About Bentrio™

Bentrio™ (AM-301) is a drug-free nasal spray intended for personal protection against airborne viruses and allergens. Upon application into the nose, Bentrio™ forms a protective gel layer on the nasal mucosa. This thin film is designed to prevent the contact of viruses or allergens with cells; in addition, the composition serves to bind such particles and help with their discharge and to humidify the nasal mucosa. Together, this is designed to reduce the risk of upper respiratory tract viral infections and promote alleviation of allergic symptoms.

About Altamira Therapeutics

Altamira Therapeutics is dedicated to developing therapeutics that address important unmet medical needs. The Company is currently active in three areas: the development of RNA therapeutics for extrahepatic therapeutic targets (OligoPhore™ / SemaPhore™ platforms; preclinical), nasal sprays for protection against airborne viruses and allergens (Bentrio™; commercial) or for the treatment of vertigo (AM-125; Phase 2), and the development of therapeutics for intratympanic treatment of tinnitus or hearing loss (Keyzilen® and Sonsuvi®; Phase 3). The Company was founded in 2003 and is headquartered in Hamilton, Bermuda with its main operations in Basel, Switzerland. The shares of Altamira Therapeutics Ltd. trade on the NASDAQ Capital Market under the symbol “CYTO”.